Lions are not hard to kill, but poly tips bullets would not be my first choice with an exception being a 22 caliber 75g V Max.
IN the 14 twists, the toughest 55g bullet is the 55g Hornady Sp with the cannalure, accuate also. Then the Sierra line of 55's all penetrate well with the 55g BTHP being the toughest of them all in the sierra line. We shot coyotes for years in Mexico with all the sierra 55's. I have killed two does with the 55g Sierra's in a 223 with a load of 26.5g of 748, they both dropped in their tracks.
The 63g Sierra is a very accurate bullet that is dependable for coyotes, deer, and cats. I shot the "Accuracy" load in the nosler manual with IMR 4350 with a Win primer. This bullet and load is especially good as the throats get shot out in your 22/250 as the longer bullet can still reach the lands.
I tried the 60g Sierra HP on coyotes in the mid 80's and it just shot holes through them, they may have changed the jacket since then, this was a VERY tough bullet.