22-250 Info

+1 for the 22-243 or the 22x47. I haven’t messed with the 22x47L personally but I did the 20cal version and loved it.

The 22-243 AI I have a lot of experience with though and that thing is a different breed of animal. Easy to load for, and an absolute rocket.
 
I've had several 22-250's, a 22-250 Ackley, and a 22-243 Middlestead, my 22x47 Lapua is the favorite of the bigger 22's.

The flyweights, gimme a 22-204.
 
I'd look for a Tikka with the 1-8 twist barrel then work up a load with the 53gr Vmax and either IMR or Hodgdon 4895.

I would prefer the 8tw Tikka 22-250 because it gives you the flexibility to shoot heavier bullets if you ever wanted to but if you have no interest in that Tikka also makes a 22-250 with a 14tw barrel and if you go with the 14tw I'd work up a load with the 52gr ELD-M and the same 4895 powder/s. I've always been a Rem 700 fan but for a factory off the shelf rifle, Tikka is realllllly hard to beat and their guns just flat seem to always shoot very well.

I pretty much only use Fed 210M's or CCI BR2's because that's just what I have. Others may work fine too.

Right now the biggest trouble you could have is finding 22-250 brass.
I just shot my new Tikka t3x lite 22-250 1:8 twist for the first time yesterday. I used PPU 55grn sp ammo to do barrel break in. I pulled the bullets on 8 rounds dumped the powder recharged the cases with 31 grn IMR 4895 seated four Hornady 75 grn HPBTs and four 75 grn Amax bullets to 2.500" COAL. Off bipod with 1-6X lpvo the BTHP grouped 0.73 moa or 0.76". The Amaxs grouped 0.88 moa or 0.93". When you can't get brass you just do what you got to do. Never had a 22-250 until now should have gotten one sooner.
 
"I plan to use it on predators and varmints and want it as flat shooting to 300 yards as I can get."

Have you looked at a 243 with 55gr B-tips at 4,000+fps?

With a 200yd zero, you'll have 12" of drop at 400yds.

That's flat!
 
I have a Brux 18” 12 twist on my 22-250. Shooting 55 grain Noslers or Vmaxes they work just fine and no POI change between the two bullets.

Looking back, it may have been smarter to go with a 9 twist to shoot the heavier bullets but not spin the small ones too fast. But honestly 55s are all I ever need for Coyotes and hardly ever shoot over 300 yards
 

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