To the OP..
I use rifles chambered for each of the cartridges you mention as calling rifles.
Starting with the .223, I've found that it's marginal for use on large coyotes. I've shot several inside 100 yards, scoring solid shoulder hits, only to have them get up and leave. Also the majority of coyotes I've shot with my .223 AR spin and bite until I can shoot them again. I would limit my shots on coyotes to under 200 yards, and stay off shoulders.
.22-250, is a very solid cartridge for coyotes. I shoot the same bullet from my .22-250 as I shoot from my .223, and have no problem with spinners or runners. My .22-250 has the energy to push bullets through shoulders and penetrate to vitals. I also like that I can hold on fur out to 300 yards with my .22-250.
.243 Winchester is very similar in performance to my .22-250 with an edge in all out killing power on coyotes. It doesn't shoot quit as flat as the .22-250 but it's not difficult to keep it on coyotes out to 300 yards. I've messed up more coyotes with my .243 than with the other two calibers but 80% of the time it's fur friendly enough that I could keep the hides. As for energy at over 300 yards? I shot one 4 years ago at 430 yards and hit it in the rear hip. The 85 grain HPBT left a fist size exit. I recovered that coyote after it drug itself into a nearby waterway. I don't believe a .223 would have even slowed it down with the same hit at that range.
I find myself using my .22-250 more often than the other two cartridges but would just as quickly pull out my .243. I've pretty much stopped using a .223 for a calling rilfe, even going to a 6.8 SPC AR as a calling AR.