Look at the thread entitled what's your favorite Coyote Round (or something to that effect). I currently do not own a .22-250 Remington, but have had several over the years. It is a great cartridge, and the rifles I have had have all been very accurate. However with the wrong bullets it is super explosive, but then most are.
On the other hand I have 2 Rifles chambered for the .223 Remington Cartridge. I have always been impressed with the preformance afforded by the small capacity .223 Remington Case. It has a mild appetite for powder, but yet produces quite impressive ballistics for what it is. If I want something with more reach than a .223, I normally reach for a .243. However the .243 is not pelt friendly, but with some of todays new bullet designs and powders it outclasses the .22-250 IMHO.
Look at it like this, the .223 & .22-250 both shoot the same bullets. These bullets were designed for a specific range of muzzle velocities, but for which one the .223 or the .22-250? Bullet weight per bullet weight the .22-250 burns roughly 1/3 more powder than a .223 to achieve roughly 400 FPS more velocity. Yes this added velocity makes the .22-250 a longer range choice. However that extra 400 FPS only adds roughly 50 yards to the Point Blank Range of the cartridge.
The Point Blank Range of a Cartridge is the maximum distance in which you can hold dead on a target(or animal), and hit within a specific number of inches of point of aim. I like to zero my Varmint Rifles to have a midrange height of 1.5" (otherwise I have a tendency to shoot over the animal at the midrange between the gun and the range where it is zeroed). Given my 1.5", then the Maximum Point Blank Range would be the distance in which my bullet falls to 1.5" below the line of sight.
When both the .223 & .22-250 are shooting the same bullets, and zeroed so the midrange height is 1.5", the maximum point blank range is only increased roughly 50 yards for the .22-250 over that of the .223.
Now that I have you thoroughly confused, maybe someone can explain it better.
SD Handgunner