Big Mike,
I was where you are a few years back. I weighed cost to shoot vs. ballistic performance. As I looked through the ballistics (keeping versatility in mind) I settled on the .243. Can shoot varmints, antelope, deer... Factory loads from 55gr Ballistic Silvertips up to 100gr.
The .243 55 grainers outperform MANY (not all) factory loads in .22-250 downrange. Have not heard too many complaints about throat erosion in the .243...
Only thing I don't like is payin' $1.45 for a coyote round, but I knew that goin' in. /ubbthreads/images/graemlins/confused1.gif