I vote for the 243 for coyotes and with the right load, it will take care of any deer. It is flatter shooting with less recoil than a 270, and is bad medicine on coyotes. I load the 70 grain Sierra Blitz King and it will flat out do the dirty deed on the coyotes. The 270 is a fine all around gun, but it kills coyotes a lot deader than they need to be.