Nosler,
You can find .243 ammo a lot eaier than 6mm, The 6mm allows you to take a slight advantage when reloading.
Also the twist on the 6mm will shoot the bigger.243 bullets a little bit better than the .243, as the .243 will probably shoot the smaller bullets a tad bit better.
Barrel and case life should be about the same.
I love my 6mm enough to keep it even though ammo is a little esier to find for a .243.