Good luck, Flybuster! I think that the secret is not to try and push them as hard as I am. I would try some IMR 4831 first and your velocity will be in the 3250 range.
Quarterbored, I don't know how long the brass will last. I have a set of 50 that I have fired 15+ times.
I do believe that the key to long brass life is to neck size when ever possible, then graduate to a shoulder bumper die (forester neck sizer) bumping the shoulder back .002, then full length size when the base gets swolen to where the bolt is tight to close.
You know, lot# of powders can vary greatly. When I get a new keg of R#19, I will back off 3g and work up to what ever is the most accurate. 57.5g in the next lot that I get may be way too hot!
When I was talking about getting 3650 out of the 100's, it was in a custom, minimum spec SAAMI spec match chamber, with tight throat(.0005 over bullet dia), and zero freebore with a 26" barrel. There is a gunsmith in Texas that makes a good living chambering nothing but this caliber with this type of reamer.
By using a chamber like this, you trap all the gas behind the bullet working for you in higher velocity with extreme accuracy.
The key to R#25 is Winchester brass and a Federal Magnum 215 Primer. R#25 without the 215 yields terrible groups.