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Your question: I was wondering if you can effectively sight in a rifle at 25 yds and still be on out to 100 - 150 yds?
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Yes you can and with out firing a shot.
If you bore sight at 25 yrds,then most rifles will shoot pretty damn good at 100 -150.
I have bore sighted many many rifes in the last several years and all at 30 yds, right from inside my house. It would be a rare except if I ever had to shoot over 3 shots to have it printing 1" high at 100. This is with the scope being 1 1/2" above the bore.
I throw up a target on the edge of my garage and with the rifle in a cradle I bore sight it from the kitchen table.
Now this of course won't work with a pump or auto, so then I would shoot the rifle to print dead center at 50yds.
This has been farily accurate for me for a long time, once you learn to bore sight your rifle the same way every time, then you be able to get your shots down to just 1 or 2 and be done with.
I agree. I bore sight bolt actions at home most of the time. I will put a bipod on the rifle and use a rear bag and center the bore on an object like a roof vent, lamp post, or other sharp object on one of the neigbors roofs down the street-(from well inside my house). Then I move the cross hairs to the best guess of where the center of bore is aiming. It will usually get me within about 5-6 inches of the center of target at 100 yards. Once your on paper, you should be able to get where you want to be in another shot or two. You can also do this at the range by centering your bore on a corner of the target and making the adjustments.
I own a boresighter with a complete set of studs, but I only use it on rifles other than bolt actions. You can get closer by bore sighting with practice. Hunters that travel far distances will practice this, along with verifing the accuracy of the scope once they get into camp.