What rifle is it? Some of the early rifles had slow twist rates that don't like the longer heavier bullets. My Savage M99 has the 1-14 twist and won't shoot the 100 grain bullets that well, especially the ones with the plastic tips. It does very well with 87s and 75s, I use the 87 grain Speer Hot Core bullet for deer with great performance.
The 250 isn't that picky about powders, I've used H4895, Varget, RL-15, 4320, and Big Game in both of mine.