I just got done testing about 12 different loads in my new Savage Predator in '250. I was using Nosler 40 grainers over 38 gr. of Varget. My MV was right at 4,000 fps, but my rifle did not like them with the powder I was using--I probably will not try the 40 gr. VMax even though I have them on the shelf.
I was only shooting at 50 yards due to some range contraints, and the group was right at 1". I will shoot them again at 100 yards to see what they do, but I settled on a 55 gr. Hornady SP load that shot a one hole, 3 shot group in my Predator with 35 gr. of Varget.
Good Luck!
Tim