5.56mm ammo is loaded a bit hotter than 223 and should not be fired in standard 223 chambers. Several hybrid chambers allow use of the GI ammo, such as the "Wilde" chamber. Here is reply from Bushmaster regarding their CMP & fluted varminter bbls. which have a hybrid chamber.
Chambers, DCM/CMP & 24" Fluted Varminter
The DCM/CMP & 24" Fluted Varminter barrels have a custom match hybrid chambering that uses the tighter SAAMI Spec headspace from the shoulder of the chamber to the bolt face. It has the longer "Leade" or throat that will accommodate the 5.56mm ammunition so it can be used without developing higher pressures as in a .223 caliber chamber that have a shorter "Leade" or throat.
Both 5.56mm and .223 caliber ammunition can safely be used in the DCM/CMP & 24" Fluted Varminter rifles.
Regards,
hm