I've been using Varget for my .223s, .243s & .308s with very good results. I have several canisters of other powders that are pretty much useless to me now. That was the idea, make it simple.
I've never got Varget to work in anything larger than a 22-250? Just tried some again in my 243 with a 65gr. V-Max. It shot all over the target,went with IMR 4064,and bingo,one ragged hole! Ron