I am more of the proponent of the flat-shooting, high to medium B.C. bullets, with high velocity VS. the idea of lobbing High B.C. bullets, i.e. 6.5 Grendel. I prefer the 243 WSSM with a standard twist using a 75gr-95gr 6mm bullet or even an 8-twist barrel if you want the 105gr, High B.C. bullets that remain very flat out of the 243 WSSM.