let me preface to say that i'm not terribly familiar with the grendel... but a few general things to think about
do you already own another firearm in either caliber? are you a reloader? whats your intended purpose for the gun?
not having to stock components/ammo for two calibers is a big consideration for some folks. and coming out of the ammo shortage of recent history - unfortunately any of us who shoot in even moderate volume are in a situation where you almost have to have your own ammo shelf.
im a LR308 owner (the dpms version of the ar10) and i choose 308 because of commonality. its a known commodity. the list of available components for reloading, as well as factory ammo offerings is longer than a 8yr old's christmas list. there are SO many things that work, even in a pinch you could probably come up with powder/primer/bullets of a combination that'll give ya stuff to push a bullet down the bore. add to that the (relative) ease of access for getting milsurp brass to reload with & its hard to not call it a winner. the most recent batch of Lake city 7.62 brass i picked up was under $0.10/ea for raw brass. fully processed can be had for a few cents more per. the cheapest grendel brass i can see starts at about $0.60 per.
from a quick google its relatively easy to convert grendel brass from 7.62x39 brass, but that can be a trick to find too from time to time - most of the military x39 you find is steel cased.
the 6mm ar (grendel, spc, 6x45, etc) offerings have the bonus of the BC over many of its 30 caliber offerings so they have that going for them.
one other consideration - the ar15 platform is going to end up (in most instances) significantly lighter than most AR-308 platforms. You'd have to put a big heavy bull barrel on an ar15 upper to match the weight of even a 16" typical 308. so if this is going to be a walking hunting rig where weight is a significant consideration.... the grendel may come out right on top from that perspective alone. as a stationary deer blind hunter the extra pound or two doesnt bother me and a long hike with my rifle will be around ½-1 mile tops. so hiking around with a 10lb 308, or bull barrel 300blk that comes in at 9 lbs isn't an issue for me. If i were more of a stalking type hunter where i was trying to cover a lot of ground... i'd be looking to shave every ounce i could and probably be hunting with a lightweight ar15 type build.
hopefully this'll help give you a few thoughts to narrow down your decision
good luck and remember once you get one or the other