I would keep it at 27", a 22" 6 AI just does not make sense. The fad these days is to have short and light for ease of carry. If you want a truck, gun then I can see the need for a 22", otherwise no.
My load for a 10" twist 6 Rem AI is 49.8g of Win 760 with the 70g Nosler at 3890 fps. Pressure increased with the 87g bullets so I had to FL size with them, so I stuck with the 70's for that reason.
Another issue, is your throat length. Your rifle will not shoot worth a darn jumping bullets very far, that will become an issue for you to measure when you receive your rifle, and will determine what bullet your rifle will more than likely shoot.
jeremiah1757,your quote,"Was hoping to cut it down to around 22" as 99% of my shots will never come close to even the 500 yard mark." I am curious what is your line of thinking on this?
The 6 Rem AI is a fantastic cartridge, fast speed with all bullets.
Jeremiah1757, your comment,"Also with the 1/8 twist what is the lightest bullet that you would try."
What will determine the answer to this question the length of your throat, again bullets do not like jumping a long ways.
If you do not have a tool to measure the over all cartridge length to where the bullet touches the lands, you need to purchase one right away, either a Davidson Ogive gauge or a Hornady(Stony point). These are a must for achieving the best accuracy in measuring the over all length to where the bullet touches the lands. Measuring off the tip of the bullet only gets you in the ball park.
Good luck