first it proves the bunch who are the ones that are known for running loads into the unknown are still using the case design. One reason may be inherent accuracy, which I will also yield to the AI vs it's parent, but second is that I beleive the changed parameters of the new case design allow it to hold higher pressures or at least to have them present themselves in other ways. Wether that means it is right or wrong, it is the data I see. The cases seem to exhibit less pressure signs, but still when run too high, will not only maintain their primer pockets longer, but also seem to displace some pressure in other areas than the locking lugs and their seats. That to me, with lug seats and surfaces making 100% contact, and quite often in stainless actions, is worth everything right there. Gauling is now less of a concern on the load horizon in an action that even if a factory one to start, has now come close to the price of a custom by the time the smith finishes with it. Not only do I save brass life at higher pressures, but I save machine shop bills at the same time for anything from lug set-back to throat life. Those I'll take any day of the week, as do quite a few BR shooters, hence the "improved" design being so prevalent with respect to all other versions of case changes.
as far as 250+ fps increase, I got it in a match chamber in a 1:8 twist PacNor, so my internal tolerances were tighter than a rechambered factory bore. That may be the reason for increased velocity over others data. I was also running a bullet of ~.625BC which means a long bearing surface and more of a seal creating a higher and faster pressure curve also adding to the velocity increase. However, when you can get to 3208fps with a 140gr a-max in a 6.5-06AI out of only a 26" tube, you are wayyyyyyyyy overpressure. That is NOT arguable,..and when I saw the chrono reading from the first string, the remainder were taken home for de-construction. The cases exhibited not the slightest increase in bolt lift in a sako action that was making great lug contact, the primers were only slightly larger in dia inside the pocket, and craters looked no worse than the strikes around factory rounds in factory rifles. I saw absolutely zero evidence of pressure, yet the cases held what I am bettting was well into the mid 70K psi range. I even reloaded them and got 2-3 more firings on the pockets before I decided I was satisfied with my test of how well they held the pressure. I have never gotten to that high in a non-AI caliber (unless it had the 35-40* shoulders and very little if any taper to begin with) without a good list of signs saying "back off some... hotrod".
Not to say Ackelys are the be-all and end-all of the cartridge world, but I have found them to exhibit some very favorable symptoms, when run too high in the pressure arena. I am partial to the lessened stresses they seem to convey to the action when a load error is made, or in the case that your rifle likes it's load best, right at the pressure edge. Saving lug integrity is always tops on my list. Their straightness is responsible for group size, so setting them back or gauling them is not prefferable.
MHO, if you stick to no more than 60,000psi, you'll be fine. Remember, lots of the old chamberings still exhist in a lot of older military actions which will not hold pressures like todays rifles, so their load specs are conservative. Also, they may be based on older, less powerful propellants. And then some with the sharp shoulders will quite often run a bit higher in the pressure ranges.
as a general rule,..I would look to go no more than 1-2gr over any book max. If no harmonic can be found at those charge ranges, then your best bet is to settle for the harmonic exhibited further back down the load ladder and run with that one. Also, if you are using a min-spec or match chamber, you will most likely NOT reach a book max. The tighter chambers and nks, at least in my rifles, won't make it to book max before they are at max in these chambers. Be aware of this when moving to tighter chambers, especially in a match barrel blank that will also run a tighter groove dimension most of the time as well.