All the 105s I've used on coyotes were messy.
Really messy.
105 Berger VLDs and 105 Amax from my WSSM at right around 3150 fps.
I'm assuming the 6x284 will have them going plenty faster than this. (depending on powder choice and barrel length)
I'm also building a 6x284 and I've got 105 Hybrids to use also. I don't PLAN to use them for coyotes...but that doesn't mean that I won't.
I've got a second build planned for next winter as well.
Gonna call it the 22 HYPR