I use a 22-250 and I've always shot them in the neck with a 55 gr VMAX load. I keep all my shots within 200 yards though and if I am unsure about my shot, I don't take it. I've had to pass on a few deer because I couldn't get a clear shot but that happens unfortunately. Better to do that than to wound an animal in my opinion. I've used Remington 55 gr PSP and those work for behind the shoulder really well too, my gun just likes the VMAX better. Being a 1-14 twist barrel yours cant handle them but anybody with a 1-10 twist barrel like mine should know they can shoot the 64 gr Winchester powerpoints extremely accurately and you can place those anywhere and they'll work great. I've shot one deer with a VMAX in the heart/lungs area and it worked great, the deer fell right where it was standing, i just like to have an exit wound when shooting that area. it did break the rib and pierce the heart and lungs but i worry if you shot too far forward and hit the shoulder it wouldn't make it all the way to the boiler room.