I agree that the single stacks will be "different" if you have big hands, but if weight is a concern, there is not much substitute when carrying IWB.
I have a G43 and HK VP9, world of difference in grip comfort and carry comfort. They are complete opposites on that front. I have carried both, but I think the G43 will get more time, just because it's easier and I don't like wearing heavier clothes to conceal the larger pistol. I shot a lot of single stack 9mms and none of them were all that comfortable in my hand, but that's life; trade-offs.
HK makes a VP9SK that is a little larger than American subcompacts, but uses the same grip inserts as the full size pistol I think. I haven't held one yet, but I bet it would be great.