Tikka 22-250 compact model, hand loads, 300yds. is where I stop, I have killed out that far but missed more at that distance than any. When hunting in Missouri my shots are generally closer, 50yds. out to 250 yds. give er take. Always shooting off my stick. I like to let them come in close, close as possible, love that adrenalin rush when I see the guard hair standing up!! I am pretty much on 10x with my optics in the open, 4x in the timber...
[ I will use my 1967 Remington Varmint 22-250 every now and thin, smooth]