I kind of had the same thoughts on round count. I think some may put to much into that. I am in the midst of reassembling a 224 Clark. Warned by numerous people that maybe less than 1000 rounds maybe way less. I am still going through with it.
Say it last 700 rounds, at 100 rounds a year that is seven years, and that would be an absolute miracle at that amount per year probably 50 or less for me.
I am going to use a 220 Swift till the Clark rig is up and running. The Swift is new to me as well. I ran a 22-250 for a number of years with no ill effect of accuracy.
If my 17 Remington was not set up for prairie dogs, I would have used it, full bull 28” barrel and a KRG Bravo full of lead shot, not my idea of a calling rig.
To the OP, if you just want to change up rigs, figure what works for you. A lot of good calibers out there. If you want store bought ammo, the 6CM is hard to argue if you like the 22 CM.
As I mentioned initially, a good varmint bullet will gain more than a poor bullet with a great cartridge.