Can't say on a Dillon.
But I have, and strongly recommend, a Hornady LNL Progressive. Caliber changes are about a minute. Changing the shell plate takes about 5 minutes if you need to do that too.
Calliber swap requirements: dies, lock n load busings for the dies, maybe a new shell plate, and a Case Activated Powder Drop Low Assembly part number 050066 (explained below).
The powder measure is one of the best out there, and you can buy lock n load powder adjustment stems so that once you get it set for your pet load in a caliber, you just pop it in. You purchase one for each of your favorite loads.
If you load multiple calibers, buy one of these for each caliber.
The powder measure sits on a Case Activated Powder Drop Low Assembly (think powder die). It needs to be adjusted for the length of the case to activate the powder measure. Buy and set one up for each caliber, and you can swap out the powder measure in less than a minute. This way you don't need to buy a new measure for each caliber like you do on a Dillon. I've got 4 of these laying on my reloading bench--.45, 38 Spcl, .223, .270 Win.
Hornady Case Activated Powder Drop Low Assembly
Or part number 050066.
Since mine is the original model from about '97, my powder measure has the micometer adjuster. I write down the setting for the powder charges, and I can reset it at a later time, validate it w/ a scale and fine tune if needed in short order. They sell the micrometer stems as an accessory now.
I can crank out about 550 pistol rounds a hour, or about 400 .223--I take my time on rifle.
And now you can get a case feed for the Hornady if you want, making it as good as a Dillon 650 for quite a bit less. I feed mine manually, and it is one less thing to change for a caliber swap. The Hornady also auto indexes, but the Dillon 550 does not. BTW, even though the Dillon 650 is purchased w/o the case feed, it is impractical using it w/out one.
Natches, Midsouth and Grafs normally have the Hordandy LNL Progressive on sale for about $300.
Take a serious look at it, call Hornady/look at their web site for more info, and buy one. Hornady also has a lifetime warrenty.
Lots of people are dedicated to their blue coolaid, but red is great too.
Drano