So far my go to gun is my Browning A-Bolt Synthetic Stalker in .270 Winchester with a 3-9X50 Leupold Vari-X II loaded with 130 SSTs or factory Federal 130 BTSPs. 12 out 14 deer dropped on the spot. The other two I heard fall over as they ran out of sight. Never lost one either.
I however by no means hunt with just that caliber though. I use a .243, 7 Rem Mag, 30-06, 444, 450, 308 to name a few but I find myself gravitating to the ol' 270 most of the time.