I cant say about those particular bullets because I am not sure who the manufacturer is. I think that as long as you slip one in between a yotes ribs it is not going to matter much what kind of expanding bullet that you use. Personally, I would rather use the Nosler Ballistic Tips on critters the size of coyote than I would the Hornady Vmax, but would use either if that was what I had on hand.
A speedy .22/250 AI load sure could cause some splashes on an animal if not hit right with too lightly constructed a bullet that's for sure