I am sure that there are many good loads for a 80g Nosler with many bullets.
I copied a friend on the IMR 4064, I shot it for years with the 80g Sierra single shot pistol bullet and currently on the 80g Sierra Blitz.
The load on my two Rem 700's is 39.5-41.5g of IMR 4064, Win or Rem brass with a Fed 210 primer(very important), with a velocity of 3450 fps. Accuracy with this load is around an inch at 200 yds or a little smaller depending on the wind. We shot this load for 20+ years on yotes...jeez does this bullet hammer a yote.
I also worked up a load for Hybrid 100that shot very well...lost that little piece of paper.
I want to try 4350 and R#17 next, just for grins. We did work up a load about 6 years ago that is straight out of the nosler manual on the 70g Nosler ballistic tip with 47g of 4350 with a Win primer(very important) that is 3600 fps out of my Rem that simply shot a single ragged hole.
I don't know how well the 80g NOsler kills...time will tell. I do know that with the 80g Sierra(single shot and Blitz)I have killed many coyotes shot in the back of the stomach(rib cage on running, broadside shots)from not leading them enough that killed them grave yard dead right there.
I worked up a load in the late 70's with H4831 with the 80's and it was only doing 3150...too slow for those super coyotes that were around back then.
I put a .243 Hart 12 twist barrel on a Remington that was 26" long and got an honest 3500 fps out of the 80g Sierra with the IMR 4064 load above, groups in the 3/8" area. I used a Bonanza/Forester neck sizer to bump the shoulder back if/when the bolt got a little tight.
If your gun will shoot the nosler 80g, I am sure that IMR 4064, IMR or H 4350, Hybrid 100, and R#17 will get stellar job with that bullet at very fast velocities.