You might try several things:
try jumping the bullet .005,.010, and .015.
Second, if you are getting a flyer I wonder if you have a stock issue.
Third, wind plays havoc with groups, sounds like this is a subject that just about everyone needs a education on, buy a $45-65 wind flag...will save you thousands in reloading components over the years.
Forth, barrels are all different.
Sixth, I shoot test groups with very high powered scopes, then swap out for hunting....really pays off.
Seventh, lot numbers of powders and bullets are very different. I shot the same load(47g) in IMR 4350 with WLR, Win case, 70g NOsler yesterday and shot an inch group at 200 yards...not bad.
Eighth, dies you use may be very important, I use Bonanza/Forester.
Nineth, number of times your brass has been fired is of critical importance, work hardened brass will throw flyers, pay attention to bullets that seat harder than others, mark that case with a Sharpie to see if that bullet flies out of the group.
Good luck