Doc,
As is widely known, extruded powders just don't throw very well. Most folks toss a "lesser" load, then trickle the load up to where they want to be. I've known some that just throw their extruded loads with all the crunching and bumping and call that "good enough".
To me that's widely inconsistent, and I can only imagine what their actual weights really are.
I agree with Steve regarding your gun maybe not liking the 60gr. bullets, and with many .22-250's, the rates of twist are generally 1 in 12, and more often 1 in 14". If your gun is of the latter, it'll generally shoot 45-55gr. bullets the best.
I've loaded the 22-250 for almost the total 35yrs. that I've reloaded, and really have never been without one. I've used just about every powder in them at one time or another, including Varget.
In my particular experiences, I've found that choices in components, even the lesser considered ones, can make big differences in group sizes. Mapping out a load for a particular gun isn't all that hard, and again, like Steve had mentioned, choosing a bullet that is conducive to your gun's rate of twist is a logical "first choice".
I've found where certain components, such as the brand of brass, bullets, or as already mentioned, primers, have given a certain level of consistency over the years, and I've tended to stick with them.
Not that I don't try other components in the place of others, as I keep different brands on hand, it's just that as an overall consensus, certain one's do better than others for the most part.
Powders that have worked very well range from IMR3031, 4895, 4064, 4350 and Varget in the extruded realm, and BL-C2, H380 and H414 in the Ball powder area. My old favorite load that used IMR4064 under a 55gr. VMax, has recently been replaced by H414. The ball powder filled the case more completely, and the Federal Match primer lights it off with no problem.
I know it's been recommended to use "magnum" primers with "any ball powder" for a more positive ignition, but I start by using a regular primer first. Especially a "match primer". They are more consistent, and usually fall in the middle as far as flame strength.
I've found that trying regular primers with given ball powders first, has in several cases, produced better accuracy than switching to magnum primers right off the bat.
If I recall correctly, Hodgdon's initial load using H380 was based on the use of a 52gr. Sierra Match bullet, and 38.0grs of the powder so aptly named.
Good luck,
Bob