Hey Bofire, those 325gr bullets will penetrate both shoulders of a moose, so I think you will be alright. They can be a bit harsh in the recoil department, but one should do. I carry a well loaded(300+ gr bullets) .44 or .45 Colt whenever I am in the woods. Bears we have plenty of, but not Mt Lions. My Uncle was a hunter for the state of Oregon a good many years ago, killed quite a few lions, main gun was a .22 mag for perfect broadside shots in a tree, and he had a .357 for when things went bad.
Dave