I'm kind of old school, I'd build a dedicated pd gun for 90% of my shooting, 20P, 204, 223/223AI and a fast twist big gun for LR. Both would be HB, no sense messing with a sporter barrel when you shooting small stuff off a rest. I wouldn't mess with a 22-250 for new LR PD rig but go to a modern sharp shouldered 224 or 6mm twisted for heavies.