Welcome Julian! I have to commend you on your fine choice of Avatar.! Us Cheeseheads and Tennesseeans got to stick together.
Ran out quick last spring and picked up my Marlin 22lr loaded with Stingers. I ended up spanking a yote at 40 yards in the front of the chest (not the best place, but he wouldn't stop). Bang-spin-run, hit him again at about 75 yards in the arse: Bang-spin-what bit me? run. Never found him. We chalked it up as a kill even though we never found blood, I think due to thick fur. I would not suggest a 22lr for yotes in my personal opinion. Shots are not always ideal and you need the extra power for those occasions.