I shot the 243 Win for over 25 years and only once did I ruin a barrel.My hunting pard and I would start warning up when the coyotes fur was prime, so we would practice every weekend in Sept. and most of Oct. We had a real nice range that went from 25 yds. out to 600yds. The first 243 I owned was a new Rem 700BDL, and I loaded my rounds cooking and shot a small bullet, after the practice for the thrird season you couldn't kit the 400yd target and couldn't group at 200 yds, I didn't think it was possible but I had washed out the throat and most of the rifling.I went and bought a new Ruger #1B in 243, changed my whole reloading of that round. I slowed it way down started shooting the 85gr Sierra HPBT at 3250fps. for the 20 years I shot it, it would shoot MOA, best group I ever shot with it was a 5/8" at a 100yds.I do think that you can ruin a good barrel with a combo of many things.