I took a nice buck antelope last season with a 22-250 and a barnes bullet, cant remember the exact one, but it has a blue tip. It was a moderate load as that was what shot the best. the shot was at 400 yards if I remember right, a buddy of mine had ranged it with the rangefinder, shot hit behind the left shoulder, and we found the bullet under the hide in front of the right shoulder. The antelope ran about 30 yards and piled up. the wound channel was on the small side, with very little lost meat, but it was obvious that the bullet did open up even at that range. that is the one and only animal that I have ever used a barnes bullet one. I usally like the regular speer, sierra, and hornaday bullets. oh and the hide damage was just a 22-30 caliber hole going in.
Wyoming recently changed our minimum calibers for big game, to include 22 centerfires for antelope and deer, and so I wanted to see what would happen. so the year before, I took an antelope at 61 yards with a 223 and a 60gr partition.
both the 223 and the 22-250 did really well, even though I felt like I was hunting with a pellet rifle with them {that's why I got so close to the one with the 223} So after both of those hunts I am still on the fence about both the barnes and the small calibers for light big game. Did I do it? yes. Did the smaller rounds and barnes bullets do their jobs, yes. am I sold on the idea that the 22 centerifres are a good choice for light big game? I don't know. both of these shots were good shots, under very good conditions, but what happens when the animal turns just as you release the shot?