I shot them in a 22 Hornet with 12.0g of 296 with win primers, 50g Ballistic tip never shot a hole through a coyote or did damage that I can remember(work up to that load in your rifle)
I shot thousands in a 222 and 223, they are very accurate bullets and if you and your rifle are capable, they will shoot 1/4" groups.
In the 223 and 222, H335 is a great powder for both cases, then again, what ever you can find these days is a good powder.