I killed a lot of predators with various Rem 788's in 222 and one Remington 700. I loaded the Sierra 45g SPT, 50g lead tip blitz, 50g spt with IMR 4198 and what you would now call LT32 powder. Great round, killed coyotes at 250 yards with regularity with the 50g bullets which show their power at 175 yards and beyond. Terrain we hunted was open dessert, rolling hills, scattered grease wood bushes, sand washes, river beds. Scope I used was a old Weaver El Passo 4x12x Steel Light or a Leupold 3.5x10x with A.O.
I tried some 40g Sierra HP, but had more nippers and spinners at longer range, so changed up the bullet to a heavier bullet. We killed around 100 or so with the 55g Sierra #1365, with no issues what so ever, about 3100 fps, they just flopped.
Forget trying to find any in a local store, but if you see any of the Rem factory 50g core loct, buy them all. Stick with Win, Rem, if you want good brass, Lapua brass trumps all if you don't eject the stuff off in the weeds. Plenty of factory loads out there, do a google search...ALL ON LINE.
The 222 is one of the very easiest cases to reload for.