Problem is, they have a larger bore to accombadate the 22WMR rounds, so naturally, the 22LR isn't as accurate.
Personally, I think the 22WMR's one of the best rounds ever, so that wouldn't be a problem for me..
Truth be told though, the 22LR's probably all anyone ever needs in a woods gun, and allot cheaper to shoot, so the S&W mentioned above's the better choice IMO.
FWIW, the only hand gun I own is a (6") 1946 K22.
But then, everyone's needs, likes, and accuracy requirements are different.
Luck