There are really way too many variables when it comes to how you setup. I feel like I to get the best opportunity to take fur on any set I avoid calling into the wind. Many have pointed out that predators will work the wind. I'd say on 90% of the dogs I've killed in the last two years have worked the wind on me. Depending on the speed of the wind let's say above 10-15 mph don't call into the wind. Your call will not be as effective because it simply won't carry as far, also if the animal is bunkered up nearby and your call gets its interest of course it will work the wind! Then you've got your back to it. If you want to optimize your chances of knocking down some fur I'd say face down wind with a nice vantage point on the land if hand calling. If you are calling with an e-call set it 30-60 yards in front of you wind blowing the call down wind the cross wind set up. I don't call a spot I think is hot if the wind isn't in my favor. Those animals are smart for the most part occasionally you run into a dumb one but those guys are usually few and far between unless they are youngins. At the same time you can ask all the people you want for advice, but I'd say go out and make your own opinion cause most of us all like different methods.