Well, for me it's going to depend greatly on losing more weight & health issues.
I've already been on a hiatus since 2009, because of health issues & weight that combined have made it hard to do my job, let alone go hunting.
I've been slowly getting better, & losing weight, but it's continuing to be a long, difficult road.
But, I have plans to be back out hunting by Fall 2011, or die trying.
So, to answer the question...
When I finally have no desire in my heart & soul to be in the outdoors, & my brain gives up, then & only then will I admit defeat.
As far as I'm concerned, I'm just taking a vacation. And that vacation WILL end sooner or later!