I have used it in .223, 20 Tac, 17 Remington, 6X45mm,and 6mmDTi and it has worked relatively well in all. It has given me top velocities in the 6mmDTi with 70 to 80gr bullets.
ab have you tried it in the .221? I would have thought it too slow for that case unless you were using heavy bullets. The burn rate I believe is about the same as N135 and H4895.