I used to be in love with the idea of a custom turret...before I started shooting a lot.
Sure, even if you keep the same load, what about environmental factors? Even if your MV doesn't change from 0°F to 100°F, air density sure does. Here in Michigan, where its FLAT, density altitude may be as great as 5000ft in the summef and as low as -2000 in the summer. At 3500ft, my 308 needs 11.75 moa at 600 yards, and at -1000ft, I need 13.5!
Can you say "holdover"? How about "miss"?
Keep yourstandard turret.