I started off with a box of cheapie white box Winchester 22-250 ammo in my 22-250, but when it came time to get serious I went with Nosler custom brass. This stuff has been great having purchased it now for 243, 204 rugers, and 22-250. I think it might be even better than the Lapua brass I bought for my 243.
I've had no good experience with new Winchester brass, and don't care for Federal either. Last couple bags of Remington, for both 204 as well as my 22 hornet were actually very good for the money. Hornady I've only used after reloading from factory stuff - but it has been acceptable.
For defect free, real tight to specs new brass though my vote would be for Nosler at this point.