I use the ladder method for my 22-250 using 50g vmax. I.had been using the superformance factory load and was shocked how slowing it down from the factory load with Varget dramatically changed my group. I seat to the COL in the hornady manual I found being two loads away from max dropped the group from 2.25 to just under 1. I think I could tweak further but will wait for the shortages to be over. Don't have the numbers with me to share. Also using CcI primers.