An old standard is around 57.0 grains of H4350 under a good quality 180 gr. bullet. My load fine tuned to 57.0 gr.s and 180 gr. Sierra SBT and is extremely accurate and very terminal on deer. My bullets are seated .025" off the lands. This load will usually clock at least around 2,750+ fps. The standard warnings apply, consult a loading manual and work up slowly and carefully.