Which one is "better" is largely going to be subjective to the parameters under which they will be compared to one another.
The 22-250 has a substantial case capacity advantage and is going to shoot every bullet faster, flatter, have less wind drift and will have more bullet energy on impact, but, does that alone make it "better," not necessarily.
It pretty much comes down to this, if those things are at or toward the top of your list of things most important, I'd say the 22-250 is what you'll deem as the "better" of the two and at one time I probably would have quickly agreed, but even though I love velocity, I've learned that just because something gets there with less elevation or windage correction, doesn't mean it's necessarily "better" than something that requires more.
I've always been a huge fan of the 22-250. I think it's one of the best all around factory varmint guns you can own, but having said that, I haven't owned a 22-250 in over 10 years and I have five .223's.