I doubt if you could tell the differance in a 7-08 with a 140 grain bullet, and your 308 with a 150 grain bullet, untill you get way out there. Two Swifts, so you basicaly have a near .243 already. I'm talking long range varmints. So now I'd still go 25-06 and stretch it out a little farther. A 243 with a 100 grain bullet will get out there a long way, but the 25-06 will do it better, IMO.