i have a v-max load for my 223's that i have no reason to change. for my 22-250, i dont have a pet load right now, but years ago i had really good luck with 50gr, and some 55gr. these varmint grenade bullets were part of an estate sale, i have 400 to 500 of them. i usually shoot 55's in both calibers. with the case capacity of the 22-250 i would like a heavier bullet.