Actually, they "should" be fur friendly from the 22/250; I shot a big groundhog this summer at 80 yards with a 50 gr. Blitz King from my .223 and there was no exit....
They are a bit expensive (I bought a box by mistake as I was intending to buy the Sierra 50 gr Blitz which is a different, cheaper Sierra bullet made for .222/.223 velocities).
However, the Blitz King is made to hold up to 22/250 velocities. Shoot a coyote with one and report back to us.