They for sure go after deer. I was bowhunting in Ohio during the peak of the rut. It was about 10:00 a.m and I had just made a few calls on the bleat can. No more than 2 minutes later, a yote can flying in and stopped right under my stand just looking around (for the deer I assume). I stuck him at 10 yards. He ran about 70 yards and went down, squirming and what not. I gave him an hour, got down out of my stand, and went over to where he went down. All I found was a pool of blood. I then hear a ruckus about 20 yards from me, he stood up in a thicket and took off with his tail between his legs. He was carrying the mail down into a creek bottom and up the other side. I then went home, figuring I'd give it longer to bleed out, and go back and get him. I went back to where I jumped him the first time around 3:00. I found a foot long section of his intestines (guess I had a gut shot). So he ran from that point without parts of his guts. Anyway, I followed the blood trail for about 100 yards and I lost it. I went up the other side where I had seen him run earlier that morning, but nothing. I looked for that thing til dark and never found him. I figure he crawled in a thicket and died. It wasn't for lack of trying though. I was upset I didn't find him.
That's my story.
I know one thing, I might give up on the can for deer hunting. Apparently I sound wounded.