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My 2 cents I use the 50 gr v max out of my 22-250 doing 3800 fps and the results on yotes are no exits so far and all DRT..they also work great on woodchucks.
there are just so many variables, I was shooting the same combo at the same speed in my 22-250, got some splashes, runners, and soft ball exits, and if the dog needed more than one shot I just about cut one in half before with that combo.