There has been a lot of good posts here.
I said before and I will say again, that accuracy comes first, Speed is nice but I don't worry about it.
The beauty of the 22-250 is most guns can use a variety of powders and bullets. In 2014 the Pdog hunt had been planned for almost a year, and powder was scarce. I had plenty of bullets so I was not too, concerned. I ended up using loads with 8208, Varget, IMR 4895,and H380. What I did, was to use each combination that had given me good results in the past. It did not matter to me if it was a 55 grain or 50 grain bullet. Speeds were not part of the equation. For three days I shot Pdogs, and had few misses. Each miss was my part.
My whole point is that with a 22-250 USUALLY,,, a man can find more than one combo to do well in his rifle. As far as powders go, there is many, as long as the correct bullet is chosen.
It was funny that the guide was bewildered, that I had so many different loads and was not having to stop and sight my rifle in. And the Pdogs did not know if I was hitting them with a 55 gr or a 50 gr. I also shot the lighter weight bullets when the wind was not blowing, and used the 55 grain pills for when the wind got up.
the RE15 and 17 both are NOT temp sensitive.
Varget and H4895 and 8208XBR are NOT temp sensitive.
IMR 4064 used to be the GO TO powder. It's still good. IMR 4985 I still use.
H-380, with a 50-53 grain is real good in my gun. These last three powders are temp sensitive, and I have had POI change at times. But I am not afraid to use them since they have proved to be very accurate for the most part.
That's seven powders in my gun, and I can bet that there are more. Yes I can count, I have not tried RE17 in my gun.
Who knows? The new Enduron Powders might have something new for some of us. I have not tried them yet. I have been looking at the CFE223 powder also.
Thanks to all who have posted here. There has been a lot of good information.